Vial 01 · Scaffold
Collagen Architecture
PDLLA 30µm non-porous microspheres. Designing the physical structure where collagen accumulates.
Vial 01 · Collagen Architecture
Collagen
Architecture
Architecture
Structure — Structural foundation for collagen regeneration
| Form | Lyophilized Powder |
| Content | 100mg / vial |
| Particle | 30µm sphere |
| Structure | Non-porous |
| Duration | 3–6 months |
| Use | Professional only |
"30µm — the size cells recognize. Not a chemical signal, but a physical structural signal."
PDLLA 30µm microspheres are engineered to match the scale of dermal fibroblasts (20–30µm). Their non-porous, high-density architecture maintains a uniform and predictable degradation rate, designing an environment where the skin regenerates on its own with minimal interference.
Mechanism of Action
01 · Implantation
Scaffold Placement
30µm non-porous microspheres establish a physical foundation within the dermis.
02 · Recognition
M2 Polarization
Macrophages recognize the scaffold and polarize toward the M2 (anti-inflammatory/regenerative) pathway.
03 · Signaling
TGF-β · SMAD Pathway
M2 macrophages secrete TGF-β, activating fibroblasts through the SMAD signaling pathway.
04 · Remodeling
Collagen Synthesis
Activated fibroblasts synthesize Type I/III collagen. Structural remodeling progresses around the scaffold.
Non-porous architecture allows surface-only degradation, maintaining a uniform collagen formation environment.
Inflammatory cell count at 12 weeks: 1/6 the level compared to porous structures.
Inflammatory cell count at 12 weeks: 1/6 the level compared to porous structures.
View ECM Prime →
Vial 02 · Environment